AbstractA comprehensive experimental investigation was conducted on blast-resistant window anchors involving 46 tests of double-pane insulated glass units (IGUs) anchored to structural steel, reinforced concrete, concrete block masonry, and stone masonry substrates. The tests were conducted using a shock tube. The windows were glazed with security films of different thickness. Different number and spacing of steel anchors were used to secure the window frames to substrates. Each window was subjected to two levels of blast loads, consisting of 28 kPa, 207 kPa-ms, and 69 kPa, 621 kPa-ms reflected pressure–impulse combinations. The windows were instrumented to measure anchor forces. The anchors developed out-of-plane shear forces and in-plane axial tension associated with postbreak membrane action. The results indicate that anchor shear forces show variations with window stiffness, substrate type, and anchor arrangements, often developing lower forces than those computed based on the static application of blast loads, indicating significant inertia resistance. Rigid substrates produce higher anchor forces. In addition to the experimental results, the paper presents single-degree-of-freedom analysis results for anchor force computation, indicating good correlations with experimental data.