AbstractFacades are exposed daily to the incidence of degradation agents such as driving rain and solar radiation. Degradation mechanisms that alter the chemical or physical structure of the material are affected according to the level of incidence of such agents, thus leading to the rise of anomalies such as ceramic tile detachment and cracks. Currently, computer simulations are used to model the action of the climate agents, however, it is not always possible to estimate all agents and factors influencing the degradation process. The combined analysis of the results of the hygrothermal simulation and the degradation indicators of the ceramic facades allows a better understanding of the degradation process and mechanisms. The objective of this research is to simulate the degradation caused by the main climate agents and obtain a statistical model able to describe degradation in ceramic facades. The degradation measurement method (DMM) quantifies the degradation of facades as a function of the affected area. The degradation trend is expressed by indicators that consider the severity of different anomalies according to the affected area. The multiple linear regression model age-weighted indicated the total radiation and thermal stress and humidifying and drying cycles as the most representative variables in degradation modeling. Ceramic facades show slight degradation up to 17 years old, and the end of service life after 25 years. From 45 years of age onwards, facades tend to be in a state of severe degradation, impairing the building performance and safety of users.