Shackman, A. J. et al. Dispositional negativity: An integrative psychological and neurobiological perspective. Psychol. Bull. 142, 1275–1314 (2016).
Guo, W., Xue, J.-M., Shao, D., Long, Z.-T. & Cao, F.-L. Effect of the interplay between trauma severity and trait neuroticism on posttraumatic stress disorder symptoms among adolescents exposed to a pipeline explosion. PLoS One 10, e0120493 (2015).
Hengartner, M. P., van der Linden, D., Bohleber, L. & von Wyl, A. Big five personality traits and the general factor of personality as moderators of stress and coping reactions following an emergency alarm on a Swiss University Campus. Stress Health 33, 35–44 (2017).
Shackman, A. J. et al. Dispositional negativity in the wild: Social environment governs momentary emotional experience. Emotion 18, 707–724 (2018).
Grupe, D. W. & Nitschke, J. B. Uncertainty and anticipation in anxiety: An integrated neurobiological and psychological perspective. Nat. Rev. Neurosci. 14, 488–501 (2013).
Barlow, D. H., Sauer-Zavala, S., Carl, J. R., Bullis, J. R. & Ellard, K. K. The nature, diagnosis, and treatment of neuroticism: Back to the future. Clin. Psychol. Sci. 2, 344–365 (2014).
Goldstein, B. L., Kotov, R., Perlman, G., Watson, D. & Klein, D. N. Trait and facet-level predictors of first-onset depressive and anxiety disorders in a community sample of adolescent girls. Psychol. Med. 48, 1282–1290 (2018).
Hakulinen, C. et al. Personality and depressive symptoms: Individual-participant meta-analysis of 10 cohort studies. Depress Anxiety 32, 461–470 (2015).
Hengartner, M. P., Ajdacic-Gross, V., Wyss, C., Angst, J. & Rössler, W. Relationship between personality and psychopathology in a longitudinal community study: A test of the predisposition model. Psychol. Med. 46, 1693–1705 (2016).
Hengartner, M. P., Tyrer, P., Ajdacic-Gross, V., Angst, J. & Rössler, W. Articulation and testing of a personality-centred model of psychopathology: Evidence from a longitudinal community study over 30 years. Eur. Arch. Psychiatry Clin. Neurosci. 268, 443–454 (2018).
Jeronimus, B. F., Kotov, R., Riese, H. & Ormel, J. Neuroticism’s prospective association with mental disorders halves after adjustment for baseline symptoms and psychiatric history, but the adjusted association hardly decays with time: A meta-analysis on 59 longitudinal/prospective studies with 443 313 participants. Psychol. Med 46, 2883–2906 (2016).
Wichstrøm, L., Penelo, E., Rensvik Viddal, K., de la Osa, N. & Ezpeleta, L. Explaining the relationship between temperament and symptoms of psychiatric disorders from preschool to middle childhood: Hybrid fixed and random effects models of Norwegian and Spanish children. J. Child. Psychol. Psychiatry 59, 285–295 (2018).
Bufferd, S. J. et al. Temperament distinguishes persistent/recurrent from remitting anxiety disorders across early childhood. J. Clin. Child. Adolesc. Psychol. 47, 1004–1013 (2018).
Spinhoven, P. et al. Prediction of 6-yr symptom course trajectories of anxiety disorders by diagnostic, clinical and psychological variables. J. Anxiety Disord. 44, 92–101 (2016).
Steunenberg, B., Beekman, A. T. F., Deeg, D. J. H. & Kerkhof, A. J. F. M. Personality predicts recurrence of late-life depression. J. Affect. Disord. 123, 164–172 (2010).
Shackman, A. J. & Fox, A. S. Getting serious about variation: Lessons for clinical neuroscience (a commentary on ’the myth of optimality in clinical neuroscience’). Trends Cogn. Sci. Regul. Ed. 22, 368–369 (2018).
Duits, P. et al. Updated meta-analysis of classical fear conditioning in the anxiety disorders. Depression Anxiety 32, 239–253 (2015).
Lissek, S. et al. Classical fear conditioning in the anxiety disorders: A meta-analysis. Behav. Res. Ther. 43, 1391–1424 (2005).
Mineka, S. & Oehlberg, K. The relevance of recent developments in classical conditioning to understanding the etiology and maintenance of anxiety disorders. Acta Psychol. (Amst) 127, 567–580 (2008).
Forcadell, E. et al. Does fear extinction in the laboratory predict outcomes of exposure therapy? A treatment analog study. Int. J. Psychophysiol. 121, 63–71 (2017).
Haaker, J. et al. Making translation work: Harmonizing cross-species methodology in the behavioural neuroscience of Pavlovian fear conditioning. Neurosci. Biobehav. Rev. 20, 20 (2019).
Scheveneels, S., Boddez, Y., Vervliet, B. & Hermans, D. The validity of laboratory-based treatment research: Bridging the gap between fear extinction and exposure treatment. Behav. Res. Ther. 86, 87–94 (2016).
Lonsdorf, T. B. et al. Don’t fear ‘fear conditioning’: Methodological considerations for the design and analysis of studies on human fear acquisition, extinction, and return of fear. Neurosci. Biobehav. Rev. 20, 20 (2017).
Boucsein, W. et al. Publication recommendations for electrodermal measurements. Psychophysiology 49, 1017–1034 (2012).
Dawson, M. E., Schell, A. M., Filion, D. L. & Berntson, G. G. The Electrodermal System. In Handbook of Psychophysiology (Cambridge University Press, Cambridge, 2007).
Kuhn, M. et al. The neurofunctional basis of affective startle modulation in humans—evidence from combined facial electromyography and functional magnetic resonance imaging. Biol. Psychiatry 10, 20 (2019).
Lang, P. J., Bradley, M. M. & Cuthbert, B. N. Emotion, attention, and the startle reflex. Psychol. Rev. 97, 377–395 (1990).
Shackman, A. J. et al. The neurobiology of dispositional negativity and attentional biases to threat: Implications for understanding anxiety disorders in adults and youth. J. Exp. Psychopathol. 7, 311–342 (2016).
Lonsdorf, T. B. & Merz, C. J. More than just noise: Inter-individual differences in fear acquisition, extinction and return of fear in humans—biological, experiential, temperamental factors, and methodological pitfalls. Neurosci. Biobehav. Rev. 80, 703–728 (2017).
Spielberger, C. D., Gorsuch, R. L., Lushene, R., Vagg, P. R. & Jacobs, G. A. Manual for the State-Trait Anxiety Inventory (Consulting Psychologists Press, Palo Alto, 1983).
McCrae, R. R. & Costa, P. T. Jr. A contemplated revision of the NEO Five-Factor Inventory. Personal. Individ. Differ. 36, 587–596 (2004).
Gerlach, A. L., Andor, T. & Patzelt, J. Die Bedeutung von Unsicherheitsintoleranz für die Generalisierte Angststörung Modellüberlegungen und Entwicklung einer deutschen Version der Unsicherheitsintoleranz-Skala. Z. Klin. Psychol. Psychother. 37, 190–199 (2008).
Bados, A., Gómez-Benito, J. & Balaguer, G. The state-trait anxiety inventory, trait version: Does it really measure anxiety?. J. Pers. Assess 92, 560–567 (2010).
Balsamo, M. et al. The state-trait anxiety inventory: Shadows and lights on its construct validity. J. Psychopathol. Behav. Assess. 35, 475–486 (2013).
Bieling, P. J., Antony, M. M. & Swinson, R. P. The State-Trait Anxiety Inventory, Trait version: Structure and content re-examined. Behav. Res. Ther. 36, 777–788 (1998).
Eysenck, H. J. Dimensions of Personality (Transaction Publishers, Piscataway, 1950).
DeYoung, C. G. Cybernetic big five theory. J. Res. Pers. 56, 33–58 (2015).
Lahey, B. B. Public Health significance of neuroticism. Am. Psychol. 64, 241–256 (2009).
Kalokerinos, E. K. et al. Neuroticism may not reflect emotional variability. PNAS 20, 20 (2020).
Buhr, K. & Dugas, M. J. The Intolerance of Uncertainty Scale: Psychometric properties of the English version. Behav. Res. Ther. 40, 931–945 (2002).
McEvoy, P. M. & Mahoney, A. E. J. To Be sure, to be sure: Intolerance of uncertainty mediates symptoms of various anxiety disorders and depression. Behav. Ther. 43, 533–545 (2012).
Saulnier, K. G., Allan, N. P., Raines, A. M. & Schmidt, N. B. Depression and intolerance of uncertainty: Relations between uncertainty subfactors and depression dimensions. Psychiatry 82, 72–79 (2019).
Boswell, J. F., Thompson-Hollands, J., Farchione, T. J. & Barlow, D. H. Intolerance of uncertainty: A common factor in the treatment of emotional disorders. J. Clin. Psychol. 69, 20 (2013).
Fergus, T. A. A comparison of three self-report measures of intolerance of uncertainty: An examination of structure and incremental explanatory power in a community sample. Psychol. Assess. 25, 1322–1331 (2013).
Allan, T. A. & DeYoung, C. G. Personality Neuroscience and the Five Factor Model. In The Oxford Handbook of the Five Factor Model (Oxford University Press, Oxford, 2016).
Altman, D. G. & Royston, P. The cost of dichotomising continuous variables. BMJ 332, 1080 (2006).
Cohen, J. The cost of dichotomization. Appl. Psychol. Meas. 7, 249–253 (1983).
McClelland, G. & Irwin, J. R. Negative Consequences of Dichotomizing Continuous Predictor Variables. https://papers.ssrn.com/abstract=627741 (2003).
Preacher, K. J., Rucker, D. D., MacCallum, R. C. & Nicewander, W. A. Use of the extreme groups approach: A critical reexamination and new recommendations. Psychol. Methods 10, 178–192 (2005).
Chin, B. et al. Intolerance of uncertainty and startle potentiation in in relation to different threat reinforcement rates. Int. J. Psychophysiol. 99, 79–84 (2016).
Dunsmoor, J. E., Campese, V. D., Ceceli, A. O., Ledoux, J. E. & Phelps, E. A. Novelty-facilitated extinction: Providing a novel outcome in place of an expected threat diminishes recovery of defensive responses. Biol. Psychiatr. 78, 203–209 (2016).
Morriss, J., Christakou, A. & van Reekum, C. M. Intolerance of uncertainty predicts fear extinction in amygdala-ventromedial prefrontal cortical circuitry. Biol. Mood. Anxiety Disord. 5, 20 (2015).
Morriss, J., Christakou, A. & van Reekum, C. M. Nothing is safe: Intolerance of uncertainty is associated with compromised fear extinction learning. Biol. Psychol. 20, 20 (2016).
Otto, M. W. et al. Prediction of ‘fear’ acquisition in healthy control participants in a de novo fear-conditioning paradigm. Behav. Modif. 31, 32–51 (2007).
Holmes, A. J. & Patrick, L. M. The myth of optimality in clinical neuroscience. Trends Cogn. Sci. (Regul. Ed.) 22, 241–257 (2018).
Lonsdorf, T. B. et al. Navigating the garden of forking paths for data exclusions in fear conditioning research. Elife 8, 20 (2019).
Gerhard, U., Borkenau, P. & Ostendorf, F. NEO-Fünf-Faktoren Inventar (NEO-FFI) nach Costa und McCrae. Göttingen: Hogrefe. Preis DM 84. Z. Klin. Psychol. Psychother. 28, 145–146 (1993).
Krampen, G. IPC-Fragebogen zu Kontrollüberzeugungen. (Verlag für Psychologie, 1981).
Julian, L. J. Measures of anxiety: State-Trait Anxiety Inventory (STAI), Beck Anxiety Inventory (BAI), and Hospital Anxiety and Depression Scale-Anxiety (HADS-A). Arthritis Care Res. (Hoboken) 63(Suppl 11), S467-472 (2011).
Allen, T. A. & DeYoung, C. G. Personality Neuroscience and the Five Factor Model. The Oxford Handbook of the Five Factor Model (2017).
Dugas, M. J., Gagnon, F., Ladouceur, R. & Freeston, M. H. Generalized anxiety disorder: A preliminary test of a conceptual model. Behav. Res. Ther. 36, 215–226 (1998).
Freeston, M. H., Rhéaume, J., Letarte, H., Dugas, M. J. & Ladouceur, R. Why do people worry?. Personal. Individ. Differ. 17, 791–802 (1994).
Sjouwerman, R. & Lonsdorf, T. B. Latency of skin conductance responses across stimulus modalities. Psychophysiology 20, 1–11 (2018).
Sjouwerman, R., Niehaus, J. & Lonsdorf, T. B. Contextual change after fear acquisition affects conditioned responding and the time course of extinction learning—implications for renewal research. Front. Behav. Neurosci. 9, 1–9 (2015).
Sjouwerman, R., Niehaus, J., Kuhn, M. & Lonsdorf, T. B. Don ’ t startle me—interference of startle probe presentations and intermittent ratings with fear acquisition. Psychophysiology 53, 1889–1899 (2016).
Blumenthal, T. D. et al. Committee report: Guidelines for human startle eyeblink electromyographic studies. Psychophysiology 42, 1–15 (2005).
Lee, I.A., P., K. J. Calculation for the Test of the Difference Between Two Dependent Correlations With One Variable in Common. (2013).
Browne, M. W. Alternative ways of assessing model fit. Sociol. Methods Res. 21, 20 (1992).
MacCallum, R. C., Browne, M. W. & Sugawara, H. M. Power analysis and determination of sample size for covariance structure modeling. Psychol. Methods 1, 130–149 (1996).
Hamm, A. O. & Weike, A. I. The neuropsychology of fear learning and fear regulation. Int. J. Psychophysiol. 57, 5–14 (2005).
Leuchs, L., Schneider, M. & Spoormaker, V. I. Measuring the conditioned response: A comparison of pupillometry, skin conductance, and startle electromyography. Psychophysiology 56, e13283 (2019).
Barrett, J. & Armony, J. L. Influence of trait anxiety on brain activity during the acquisition and extinction of aversive conditioning. Psychol. Med. 39, 255–265 (2009).
Indovina, I., Robbins, T. W., Nez-Elizalde, A. O., Dunn, B. D. & Bishop, S. J. Fear-conditioning mechanisms associated with trait vulnerability to anxiety in humans. Neuron 69, 563–571 (2011).
Sehlmeyer, C. et al. Neural correlates of trait anxiety in fear extinction. Psychol. Med. 41, 789–798 (2011).
Tzschoppe, J. et al. Aversive learning in adolescents: Modulation by amygdala-prefrontal and amygdala-hippocampal connectivity and neuroticism. Neuropsychopharmacology 39, 875–884 (2014).
Kuhn, M. et al. Mismatch or allostatic load? Timing of life-adversity differentially shapes gray matter volume and anxious-temperament. Soc. Cogn. Affect. Neurosci. 20, 20 (2015).
Sheehan, D. V. et al. The Mini-International Neuropsychiatric Interview (MINI): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 59, 22–33 (1998).
Scharfenort, R., Menz, M. & Lonsdorf, T. B. Adversity-induced relapse of fear: Neural mechanisms and implications for relapse prevention from a study on experimentally induced return-of-fear following fear conditioning and extinction. Transl. Psychiatry 6, e858–e868 (2016).
Scharfenort, R. & Lonsdorf, T. B. Neural correlates of and processes underlying generalized and differential return of fear. Soc. Cogn. Affect. Neurosci. 20, 612–620 (2016).
Venables, P. & Christie, M. Electrodermal activity. In Techniques in Pychophysiology (eds Martin, I. & Venables, P.) 3–67 (Wiley, Chichester, 1980).
Lykken, D. & Venables, P. Direct measurement of skin conductance: A proposal for standardization. Psychophysiology 8, 656–672 (1971).
Ashburner, J. A fast diffeomorphic image registration algorithm. NeuroImage 38, 95–113 (2007).
Fullana, M. A. et al. Neural signatures of human fear conditioning: An updated and extended meta-analysis of fMRI studies. Mol. Psychiatry 20, 20 (2015).
Lonsdorf, T. B., Haaker, J. & Kalisch, R. Long-term expression of human contextual fear and extinction memories involves amygdala, hippocampus and ventromedial prefrontal cortex: A reinstatement study in two independent samples. Soc. Cogn. Affect. Neurosci. 20, 20 (2014).
Sehlmeyer, C. et al. Human fear conditioning and extinction in neuroimaging: A systematic review. PLoS One 4, e5865 (2009).
Tovote, P., Fadok, J. P. & Lüthi, A. Neuronal circuits for fear and anxiety. Nat. Rev. Neurosci. 16, 317–331 (2015).
Herry, C. & Johansen, J. P. Encoding of fear learning and memory in distributed neuronal circuits. Nat. Neurosci. 17, 1644–1654 (2014).
Greco, J. A. & Liberzon, I. Neuroimaging of fear-associated learning. Neuropsychopharmacology 41, 320–334 (2016).
LaBar, K. S., Gatenby, J. C., Gore, J. C., LeDoux, J. E. & Phelps, E. A. Human amygdala activation during conditioned fear acquisition and extinction: A mixed-trial fMRI study. Neuron 20, 937–945 (1998).
Büchel, C., Morris, J., Dolan, R. J. & Friston, K. J. Brain systems mediating aversive conditioning: An event-related fMRI study. Neuron 20, 947–957 (1998).
MacNamara, A. et al. Neural correlates of individual differences in fear learning. Behav. Brain Res. 287, 34–41 (2015).
Furmark, T., Fischer, H., Wik, G., Larsson, M. & Fredrikson, M. The amygdala and individual differences in human fear conditioning. NeuroReport 8, 3957–3960 (1997).
Ewbank, M. P. et al. Anxiety predicts a differential neural response to attended and unattended facial signals of anger and fear. Neuroimage 44, 1144–1151 (2009).
Fonzo, G. A. et al. Common and disorder-specific neural responses to emotional faces in generalised anxiety, social anxiety and panic disorders. Br. J. Psychiatry 206, 206–215 (2015).
Michely, J., Rigoli, F., Rutledge, R. B., Hauser, T. U. & Dolan, R. J. Distinct processing of aversive experience in amygdala subregions. Biol. Psychiatry Cogn. Neurosci. Neuroimaging 5, 291–300 (2020).
Stout, D. M., Shackman, A. J., Pedersen, W. S., Miskovich, T. A. & Larson, C. L. Neural circuitry governing anxious individuals’ mis-allocation of working memory to threat. Sci. Rep. 7, 20 (2017).
Fisher, A. J., Medaglia, J. D. & Jeronimus, B. F. Lack of group-to-individual generalizability is a threat to human subjects research. PNAS 115, E6106–E6115 (2018).
Hedge, C., Powell, G. & Sumner, P. The reliability paradox: Why robust cognitive tasks do not produce reliable individual differences. Behav. Res. Methods 20, 1–21 (2017).
Charpentier, C. J. et al. How Representative are Neuroimaging Samples? Large-Scale Evidence for Trait Anxiety Differences Between MRI and Behaviour-Only Research Participants. https://osf.io/cqdne (2020).
Dunsmoor, J. E., Bandettini, P. A. & Knight, D. C. Impact of continuous versus intermittent CS-UCS pairing on human brain activation during Pavlovian fear conditioning. Behav. Neurosci. 121, 635–642 (2007).
Lissek, S., Pine, D. S. & Grillon, C. The strong situation: A potential impediment to studying the psychobiology and pharmacology of anxiety disorders. Biol. Psychol. 72, 265–270 (2006).
Hugdahl, K. & Ohman, A. Effects of instruction on acquisition and extinction of electrodermal responses to fear-relevant stimuli. J. Exp. Psychol. Hum. Learn. 3, 608–618 (1977).
Haaker, J. et al. Deficient inhibitory processing in trait anxiety: Evidence from context-dependent fear learning, extinction recall and renewal. Biol. Psychol. 111, 65–72 (2015).
Arnaudova, I. et al. Individual differences in discriminatory fear learning under conditions of ambiguity: A vulnerability factor for anxiety disorders?. Front. Psychol. 4, 298 (2013).
Chin, B., Nelson, B. D., Jackson, F. & Hajcak, G. Intolerance of uncertainty and startle potentiation in relation to different threat reinforcement rates. Int. J. Psychophysiol. 99, 79–84 (2016).
Joos, E., Vansteenwegen, D. & Hermans, D. Worry as a predictor of fear acquisition in a nonclinical sample. Behav. Modif. 36, 723–750 (2012).
Torrents-Rodas, D. et al. No effect of trait anxiety on differential fear conditioning or fear generalization. Biol. Psychol. 92, 185–190 (2013).
Craske, M. G., Treanor, M., Conway, C. C., Zbozinek, T. & Vervliet, B. Maximizing exposure therapy: An inhibitory learning approach. Behav. Res. Ther. 58, 10–23 (2014).
Haddad, A. D. M., Pritchett, D., Lissek, S. & Lau, J. Y. F. Trait anxiety and fear responses to safety cues: Stimulus generalization or sensitization?. J. Psychopathol. Behav. Assess. 34, 323–331 (2012).
Gazendam, F. J., Kamphuis, J. H. & Kindt, M. Deficient safety learning characterizes high trait anxious individuals. Biol. Psychol. 92, 342–352 (2013).
Kindt, M. & Soeter, M. fear inhibition in high trait anxiety. PLoS One 9, 20 (2014).
Reiss, S. Trait anxiety: It’s not what you think it is. J. Anxiety Disord. 11, 201–214 (1997).
Mathews, A., Ridgeway, V. & Williamson, D. A. Evidence for attention to threatening stimuli in depression. Behav. Res. Ther. 34, 695–705 (1996).
Nelson, B. D. & Shankman, S. A. Does intolerance of uncertainty predict anticipatory startle responses to uncertain threat?. Int. J. Psychophysiol. 81, 107–115 (2011).
Lang, P. J., Greenwald, M. K., Bradley, M. M. & Hamm, A. O. Looking at pictures: Affective, facial, visceral, and behavioral reactions. Psychophysiology 30, 261–273 (1993).
Mauss, I. B. & Robinson, M. D. Measures of emotion: A review. Cogn. Emot. 23, 209–237 (2009).
Lindner, K. et al. Fear-potentiated startle processing in humans: Parallel fMRI and orbicularis EMG assessment during cue conditioning and extinction. Int. J. Psychophysiol. 20, 1–11 (2015).
Beckers, T., Krypotos, A.-M., Boddez, Y., Effting, M. & Kindt, M. What’s wrong with fear conditioning?. Biol. Psychol. 92, 90–96 (2013).
Jovanovic, T. & Ressler, K. J. How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD. Am. J. Psychiatry 167, 648–662 (2010).
Ressler, K. J. & Mayberg, H. S. Targeting abnormal neural circuits in mood and anxiety disorders: From the laboratory to the clinic. Nat. Neurosci. 10, 1116–1124 (2007).
Martínez, K. G. et al. Correlations between psychological tests and physiological responses during fear conditioning and renewal. Biol. Mood Anxiety Disord. 2, 16 (2012).