AbstractThis paper examines the life-cycle wind resistant performance of a constructed long-span suspension bridge in the coastal region of China, aiming to quantify the multisource time-variant effects and uncertainties and offering a reference for designs of long-span bridges in the future. Randomness from modal frequencies, damping ratios, and identification uncertainty of flutter derivatives (FDs) was considered; then, their effects on probability of flutter failure and probability of exceeding the predefined buffeting response root-mean square (RMS) are discussed. Firstly, results of full-track tropical cyclone (TC) simulation under various climate warming scenarios are reviewed; then, the time-variant probability density function (PDF) of annual extreme wind speed is discussed. Secondly, 6-year modal frequencies and damping ratios of a long-span suspension bridge with a center-slotted section were extracted by fast Bayesian FFT method with structural health monitoring (SHM) data, which were utilized to explore the deterioration rules of structural properties. Thirdly, FDs were modeled from a probabilistic perspective based on complex Wishart distribution, which were identified in the turbulent flow and the frequency domain by Bayesian inference. The posterior distributions of FDs, namely identification uncertainty, were quantified by Markov chain Monte Carlo (MCMC) sampling. This paper finds that for flutter resistant performance, the time-variant effects (i.e., modal frequencies and PDFs of extreme wind speed) will make the flutter failure probability seven times larger than the initial value; for the probability of exceeding the predefined buffeting response RMS, however, the time-variant effects will make a negligible difference.