AbstractRapid urbanization is intensifying land use transitions in China by shrinking cropland and increasing land development, exacerbating land abuse, and causing environmental degradation. There are clear needs to improve land use and address these problems; however, most previous studies focused on either structural or layout optimization. In contrast, this paper proposed a method for comprehensive optimization of land use areas, layout, and structure. This involved coupling multiobjective dynamic planning (MODP), Conversion of Land Use and its Effects at Small regional extent (CLUE-S), and minimal cumulative resistance (MCR) models. In this approach, the MODP model predicted future changes that were based on areas of current land use, and the CLUE-S model simulated various future types that were based on the analysis of geographic land use and economic data. In addition, the MODP and CLUE-S models optimized the amounts and spatial distributions of land use types, respectively. The MCR model could then partition the simulation results for ecological optimization. In this paper, an illustrative application was presented that partitioned Changchun City, Jilin Province, China into construction-prohibited, restricted construction, suitable for construction, and key construction areas (which accounted for 17.41%, 30.24%, 25.32%, and 27.04%, respectively of the total area). The optimization result met expectations and provided potentially valuable reference data for spatial land use planning and ecological protection in the focal region. The proposed method to optimize the ecological layout of land use that was based on multimodel coupling considered operability and objectivity; therefore, facilitating practical applications of the results in Changchun and the presented methodology elsewhere.