AbstractThis study presents an approximated model for pressure transient simulations as well as a local wall shear stress analysis to control and dislodge biofilm growth in water distribution systems. It demonstrates the potential of taming hydraulic transients to manage and disrupt the growth of biofilm colonies attached to the inner walls of pipeline systems. The systems are subjected to consecutive controlled transient pressure waves by manipulating valves positioned strategically along the water distribution system. Because the controlled transient waves are generated at different locations in the system, the interference properties of the waves can be capitalized on at points where different pressure waves can come together and merge in the system, thus creating high pressures and powerful shear stresses. Nevertheless, it is vital to keep the head pressure confined within the allowed pressure range to avert extreme devastating pressures and ensure the integrity of the system. Three case study applications of increasing complexity are presented to demonstrate the potential of this approach. These transient wave simulations implemented the Lagrangian-based wave characteristic transient model, and the optimization of valve operation was governed by an evolutionary genetic algorithm. The results indicate that it is possible to trigger transient events for biofilm management purposes without exceeding the allowed critical pressure in various network layouts.